PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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Benzyl (6-hydroxyhexyl)carbamate
0 ImagesCat. No.: HY-W097012CAS No.: 17996-12-2
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10-((2,5-Dioxopyrrolidin-1-yl)oxy)-10-oxodecanoic acid
0 ImagesCat. No.: HY-W108239CAS No.: 159350-38-6
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14-((2,5-Dioxopyrrolidin-1-yl)oxy)-14-oxotetradecanoic acid
0 ImagesCat. No.: HY-W129735CAS No.: 146004-82-2
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4-(Chloromethyl)phenylacetic Acid
0 ImagesCat. No.: HY-W613504CAS No.: 56066-91-2
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Boc-cyclohexane-piperazine-Ac-Ph
0 ImagesCat. No.: HY-W293394CAS No.: 1248730-88-2
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tert-Butyl N-cis-(3-formylcyclobutyl)carbamate
0 ImagesCat. No.: HY-W056857CAS No.: 171549-91-0
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Ethyl 4-oxobutanoate
0 ImagesCat. No.: HY-W612170CAS No.: 10138-10-0
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4-(Aminomethyl)bicyclo[2.2.2]Octan-1-ol
![4-(Aminomethyl)bicyclo[2.2.2]Octan-1-ol](https://file.medchemexpress.com/product_pic/hy-w389728.gif "Click to View 4-(Aminomethyl)bicyclo[2.2.2]Octan-1-ol Product Detail")
0 ImagesCat. No.: HY-W389728CAS No.: 72948-92-6
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Benzyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalic acid
![Benzyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalic acid](https://file.medchemexpress.com/product_pic/hy-w126745.gif "Click to View Benzyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalic acid Product Detail")
0 ImagesCat. No.: HY-W126745CAS No.: 1893054-22-2
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Azido-PEG11-alcohol
0 ImagesAzido-PEG11-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG11-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(m-PEG4)-N'-(amino-PEG3)-Cy5
0 ImagesCat. No.: HY-141056CAS No.: 2107272-96-6
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tert-Butyl N-{2-azaspiro[4.5]decan-8-yl}carbamate
![tert-Butyl N-{2-azaspiro[4.5]decan-8-yl}carbamate](https://file.medchemexpress.com/product_pic/hy-w056052.gif "Click to View tert-Butyl N-{2-azaspiro[4.5]decan-8-yl}carbamate Product Detail")
0 ImagesCat. No.: HY-W056052CAS No.: 1341038-05-8
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8-Iodooct-1-yne
0 ImagesCat. No.: HY-W667003CAS No.: 60754-50-9
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1-(1,1-Dimethylethyl) 4-(4-boronobenzoyl)-1-piperazinecarboxylate
0 ImagesCat. No.: HY-W000858CAS No.: 1150114-76-3
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1,4-Di(3-hydroxypropoxy)butane
0 ImagesCat. No.: HY-W442085CAS No.: 2052305-98-1
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Potassium (3-bromopropyl)trifluoroborate
0 ImagesCat. No.: HY-W802645CAS No.: 1262538-15-7
